sqlite_escape_string() will correctly quote the string specified by item for use in an SQLite SQL statement. This includes doubling up single-quote characters (') and checking for binary-unsafe characters in the query string.
If the item contains a NUL character, or if it begins with a character whose ordinal value is 0x01, PHP will apply a binary encoding scheme so that you can safely store and retrieve binary data.
Although the encoding makes it safe to insert the data, it will render simple text comparisons and LIKE clauses in your queries unusable for the columns that contain the binary data. In practice, this shouldn't be a problem, as your schema should be such that you don't use such things on binary columns (in fact, it might be better to store binary data using other means, such as in files).
addslashes() should NOT be used to quote your strings for SQLite queries; it will lead to strange results when retrieving your data.
See also sqlite_udf_encode_binary().
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